“Carry the biggest gun you can tote comfortably and shoot accurately. The reason being is if it is not Comfortable you will leave it at home in the gun safe instead of having it in your pants when you need it and if you can’t shoot it accurately, well, what are we really talking about carrying a gun for?” –Clint Smith, Thunder Ranch.
It all comes down to manual of arms and PRACTICE.
Yeah six rounds of .44 Mag should do the trick against any foe, two or four legged.
IF you can put the rounds where you need them to be ACCURATELY under STRESS.