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Those insane dudes called the Mad Duo over at Breach Bang Clear break it down and give you some great Security tips for when you have to stay in a Hotel.
Pay close attention to the improvised door security devices. Anything you can do to beef up the pitiful locks is a plus.
Remember: Fire and Crime are your two biggest concerns in a Hotel, so be cognizant of both at all times.
Also on a side note, look up Bed Bug infestations at the Hotel Chain you plan to stay at and first thing when you check-in, check the bed sheets and pillow cases. Some Nasty Stuff Folks!!
Stay Alert, Stay Armed and Stay Dangerous!